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An implication of the high degree of hepatic extraction is that clearance of nicotine should be dependent on liver blood flow. For more details and references on the pharmacokinetics and metabolism of nicotine, the reader is referred to Hukkanen et al. Menthol is widely used as a flavorant in foods, mouthwash, toothpaste, and cigarettes. As a consequence, there is little buccal absorption of nicotine from flue-cured tobacco smoke, even when it is held in the mouth Gori et al. In skeletal muscle, concentrations of nicotine and cotinine are close to that of whole blood. Cotinine is a highly specific and sensitive marker for tobacco use in the absence nicotine medication use and has the advantages of a fairly long half-life 16 h.
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The distribution half-life averages about 8 min. Quantitative aspects of the pattern of nicotine metabolism have been elucidated fairly well in people Fig. Nicotine absorption pharmacokinetics of different forms of nicotine administration in single doses modified from Hukkanen et al. The second step is catalyzed by a cytoplasmic aldehyde oxidase. Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation. Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.
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